Science does not tell us what we should do. Science can tell us what the consequences will be if we do or do not do some particular thing. Science informs us and our elected representatives, but science does not dictate what the political policy should be.
Almost every decision involves some kind of trade-off. Often, the trade-off is between safety and liberty. For example, most driving and traffic regulations involve giving up some amount of liberty in return for greater safety.
In the case of Covid-19, the use of vaccines, masks, business closings, etc. is a trade-off between safety and liberty. If you say that a Covid-19 related policy is justified if it saves even one life, then you would have a problem. The vaccine has clearly saved many lives, but some people have died from the vaccine as well. It is not as simple as choosing the one that saves the most lives. Almost everyone who wants to take the vaccine can take it. The majority of adults have already chosen to get the vaccine. The relatively few who are compromised in some way and, therefore, are advised against getting the vaccine can do a lot to protect themselves against those who might be contagious.
As a libertarian, I believe that private business owners, just like homeowners and individuals, should be free to choose whether or not to associate with those who are not vaccinated. Government, on the other hand, should really not be able to discriminate based on vaccine status in most situations because we citizens don’t really have the option to “opt-out” of dealing with the government. There may be some situations or circumstances where a vaccine mandate by the government might be appropriate, but the default position should be liberty, with the burden on the government to show why the mandate outweighs the loss of freedom. Ultimately, the decisions will be made by our elected representatives. And as we all know, there is a wide difference of opinion about vaccine mandates among our elected representatives as well as among we citizens.